临床皮肤科杂质年43卷第1期
JClinDermatol,January,Vol43,No.1
电流感觉阈值在诊断神经源性敏感性皮肤中的意义
李淑媛-1,王学民2,高延瑞3,陈双瑜4,刘小萍3,董亚琪4,樊国彪2
(1.医院皮肤性病科,上海;2.医院皮肤与化妆品研究室,上海;3.安徽医科大学附属医院,上海;4.徐州医学院附属医院,上海)
[摘要]目的:探讨电流感觉阈值(CPT)在诊断神经源性敏感性皮肤中的意义。方法:初步筛选60名自我感知为敏感性皮肤的受试者,再分别采用乳酸试验、辣椒素试验半主观评判阳性和阴性结果进行分组,乳酸试验或辣椒素试验阳性为敏感性皮肤,二者均为阴性为正常对照组。其中辣椒素试验阳性提示神经源性敏感性皮肤,并采用CPT检测方法评估各组神经敏感性。
结果:辣椒素试验阳性组和正常对照组CPT值在5Hz频率下分别为(6.67±6.37)和(11.90±8.37),Hz频率下分别为(12.67±7.61)和(26.33±13.75),2个频率两组间差异均有统计学意义(P0.05)。结论:辣椒素试验可以反映皮肤神经敏感性的改变,
CPT测试可以客观地反映皮肤神经敏感性改变的程度。故辣椒素试验结合CPT测试可以评估皮肤神经敏感性。敏感性皮肤与无髓鞘C和有髓鞘Aδ两种神经纤维有关。
[关键词]乳酸试验;辣椒素试验;电流感觉阈值;皮肤神经敏感性
[中图分类号]R[文献标识码]A[文章编号]-()01--03
ClinicalvalueofCPTinthediagnosisofneuralsensitiveskin
LIShu-yuan,WANGXue-min,GAOYan-rui,CHENShuang-yu,LIUXiao-ping,DONGYa-qi,FANGuo-biao(SkinSTDDepartment,TongjiHospitolofTongjiUniversity,Shanghai,China)
Objective:Toinvestigatetheclinicalvalueofcurrentperceptionthreshold(CPT)inthediagnosisofneuralsensitiveskin.Methods:Accordingtotheresponsestolacticacidandcapsaicintest,60subjectswithself-reportedsensitiveskinweredividedintotwogroups.Capsaicinorlacticacidtestpositivesubjectsweresensitiveskingroupandbothtestnegativesubjectsservedasnormalcontrols.Capsaicintestpositivewasclassifiedasneuralsensitiveskin.TheskinnervesensitivityineachgroupwasassessedwithCPT.Results:TheCPTateither5HzorHzwassignificantlylowerincapsaicintestpositivesubjectsthaninnormalcontrolsfat5Hz6.67±6.37forcapsaicintestpositiveand11.90±8.37fornormal;atHz12.67±7.61forcapsaicintestpositiveand26.33±13.75fornormal;P0.05forbothfrequencies).Conclusion:Thechangeofskinnervesensitivitycanbereflectedbythecapsaicintest,andtheextentofobjectivechangesinthenervesensitivitycanbedetectedbytheCPTtest.ThecapsaicintesttogetherwiththeCPTcanbeusedtoevaluatethecutaneousnervesensitivity.SensitiveskinisassociatedwithbothunmyelinatedCfibersandmyelinatedAδfibers.
[Keywords]lacticacidtest;capsaicintest;currentperceptionthreshold;skinneuralsensitivity
[JClinDermatol,,43(1):-]
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